Any advice would be greatly appreciated. ScienceDaily. My latest blood test showed a T level of 264. Of the things that are speculated by reports of people who stopped HRT, common side effects are often short lived and include: Fatigue; Headaches; Hot … The breast surgery will not be cover. 135-142. Bringing the mind and body closer together eases gender dysphoria and can help trans people feel better about their bodies. Finasteride in usually prescribed dosages (1-5 mg/day) can interfere with the progesterone->allopregnanolone conversion causing same side effects in some (fewer) MtFs, but finasteride dosage decrease to 0.05 – 0.1 mg/day (1/100 – 1/50 of a 5 mg pill once a day) prevents these side effects while giving equally strong useful effects (on hair only). I think someone listed it above taking it once every three days. Because women are twice as likely to be diagnosed with depression as men, these changes in the levels of SERT are consistent with the increased risk for mood and anxiety disorders in females relative to males. 2, pp. If my E levels are right next week when I go for my bloods, i’ll be dropping the cypro too.” EC, 1-5-18 "This study is the first to show changes in brain chemistry associated with the hormonal treatments administered in the sex change process," said Dr. John Krystal, Editor of Biological Psychiatry. The second effect: taking Spiro, for reasons that are not well understood, appears to interfere with the patient achieving expected blood levels of estradiol. She has opened my mind to my own possibilities and has enhanced my life immeasurably, Thank you Lena! In my case, I had a strange hacked up sexuality before my discovery that I am trans. It has only been 1 week, but the side effects from spiro are slowly disappearing. In two weeks at next DR. appt, I am going to ask to switch from pills to injections.”, SK, 8-1-2018. If the MTF crossdreamer brain is actually producing feminizing estrogen, this should reduce their level of anxiety, achieving much of the same effect as doctors seek when giving them estrogen and antiandrogens. Feeling much better.”, KA, Dec 2016. The effects can come quite quickly when your hormones suddenly shift. Another I will not take is Finasteride, due to it’s side effects.”, AT, 5-27-2020. I’ve taken oral estradiol 2mg/daily and 200mg/day spiro for a few months now and things have been going okay thus far but every time I start to see information like this I am filled with immense anxiety about my transition. you’re feeling attacked because you’re on spiro and you are threatened. 2- GNRH antagonists Now as far as I know from taking Spiro I haven’t had any side effects as I am reading about here . This also begs the question: could the start of Spiro-based HRT also explain increased incidence in the transgender community of self harm, addictive behavior, and suicide? See my article on Spironolactone in […], I was given 50 mg of spiro daily and .5 estridol once a week to start i think this isnt enough to get things going well, “Visceral fat cannot easily be reduced with diet or exercise and cannot be removed with any kind of plastic surgery. What would be a better option for me? The most common disastrous thoughtlessness is taking hormones while postponing facial needle electrolysis. But I agree, injectable estradiol valerate or cypionate at least 7 mg every 5 days without antiandrogen (with finasteride 0.05-0.1 mg/day in case of male pattern baldness in the past) is a safe and effective MtF HRT regimen. I don’t think I’m meant to stay on this current combination for long as I only started estrogen in August. There is also a modulation, both up and down, of panic and anxiety and ability to withstand stress. — Medical specialists and providers have seen the evidence and are finally reconsidering Spiro. I was a sex worker at one point in my life and didn’t need hormone replacement therapy. (21) “Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline”, Hembree WC, The Journal of Clinical Endocrinology & Metabolism, Volume 102, Issue 11, 1 November 2017, Pages 3869–3903 Its something important to me…. L’Affaire Spironolactone – Crash Trans Test, Des cobayes mal hormonées ? Increased dose in July 2019 to 200mg, 2x per day – same symptoms as mentioned in previous 2 dosages except much worse. And it is also of concern that unless and until it is removed, it is associated with risks of metabolic syndrome and insulin insensitivity. New research published in the current issue of Biological Psychiatry indicates that these hormonal treatments also alter brain chemistry. (20)  This visceral fat is caused by raised cortisol. I know a lot of docs and endos seem to prefer to prescribe sublingual E for months at first. Since then all the symptoms are going away. Georg S. Kranz, Wolfgang Wadsak, Ulrike Kaufmann, Markus Savli, Pia Baldinger, Gregor Gryglewski, Daniela Haeusler, Marie Spies, Markus Mitterhauser, Siegfried Kasper, Rupert Lanzenberger. In your opinion is it safe to stay on my current regimen through the holidays until I see said doctor again or would it be wise to try to discuss these concerns with my endocrinologist like, now. Epub 2006 Jun 20. I miss that wonderful feeling of inner peace, – both mental and emotional – and the more considerate person I used to be ! 5- Spiro. And I too was a much more calm and considerate person. I’m now completely off of spironolactone, feminizing rapidly, feel very healthy, and have no brain fog or other symptoms typical to longer term exposure to anti androgens. My Cardiology Doctor said all surgeries are to be cancelled until I get a MRI scan done first. Oposite of what we need. And what about the fat stored in butt and hips? “After taking it for about 4 years it started to just quit blocking T all together. Happy to hear your thoughts. Data to answer this question is lacking, but the risk seems rational and clear, and this complex of issues — brain fog, poor memory, lethargy, depression, anxiety and panic attack — are widely known in the transgender community. I take the pill form. 1 Having fewer erections may shorten the penis over time In general, trans women report they don’t get automatic erections anymore and that it … Weight loss with no hunger, no exercise. While on Spiro I experienced greater difficulty with organizing thought, more frequent thought derailment, and more reactionary and unclear thinking. Its use has persisted despite the availability of safe and effective human-identical estradiol. It was my conscious mind’s way of making peace with a reality it didn’t understand and certainly didn’t enjoy. The one that does backup some of your claims (Leinung M) is a bit flawed as it’s measuring T levels but Spiro blocks T being effective and doesn’t actually stop production. You’re going to scare the hell out of trans women with blatantly wrong statements like that. I don’t and didn’t want to start down the road. In humans, testosterone probably exerts its masculinizing influence on the brain during prenatal development (7). The medical community owes it to the transsexual community to take a second look at the overall risk/benefit ratio for the use of Spironolactone as an antiandrogen. I was ok with every thing and was always relaxed now amost everything bothers me. the hump on your neck can definitely be from raised cortisol levels. To my surprise, I found that as my body began to change on hormones, so did my sexual orientation. As an aside, ubiquitous assertion of harm from saturated fats is a huge fraud. it saved me from jumping on the spiro wagon which would have caused me unwanted problems. Both these doctors have interacted personally with myself and were an influence, and were influenced by, this very article you are reading, since its first version in 2014. the effect of hormone treatment on the brain In order to avoid confounding effects, many studies comparing the brains of trans- and cisgender people only include transgender subjects who have not yet begun treatments to bring levels of key sex hormones … I’ve heard it can be challenging to convince endos to think outside their normal box, and I live in a smaller city without a PP or many options at all for docs / endos willing to supervise HRT. Only after 3 years of treatment did at least half of patients fall into that band. “Estradiol levels of patients did not correspond with estradiol dosage administered or BMI. Research on young girls with poor Waist/hip measurements correlate to higher cortisol levels and visceral fat, as well as mobilization of fat from elsewhere in the body to the central region — the opposite of the desired fat mobilization sought by trans women. Feminizing hormone therapy, also known as transfeminine hormone therapy, is hormone therapy and sex confirmation therapy to change the secondary sexual characteristics of transgender people from masculine or androgynous to feminine. This along with unusual bruising,dizziness/unsteadiness, and chronic exhaustion prompted me to stop taking it. when I went to my 6 mth checkup my t level was like 178 and estrogen level dropped to 33 but last time when taking 25 mg of sprio my estrogen level was higher at 50 at my 3 mth checkup was it the spiro that lowered the estrogen level then ? But forgive me for being analytical – I have a science degree – but the list of references doesn’t inspire me. “Was on that crap for 21 months. Sexual responsiveness will likely diminish over the course of hormonal therapy, potentially resulting in the inability to … The emphasis is that visceral fat is caused by high cortisol levels (among other things) and requires dieting combined with a fairly substantial (though not extreme) exercise regimen to get significant improvement. As a result, "a cross-disciplinary approach is required to provide transgender people with optimal care," the report said. Your emotions might go totally haywire ... or not. I eventually added 5 mg. finasteride to this regimen per day to no avail. Spironolactone (“Spiro”) is a potassium-sparing diuretic and steroid drug frequently prescribed in the US to assigned-male-at-birth (AMAB) trans women as part of their HRT. I was on injected estradiol valerate and yet my T was at 400! After 6 months, switched to EV injections and dropped the Spiro, because of this forum. I’m just taking injectable estradiol valerate at a normal dosage, subcutaneous twice a week to keep levels more stable, and micronized progesterone. It neither changed my state of being, mind nor disposition as was proven out by my periodic bloodwork. What’s worse is that the paper you use (20, http://onlinelibrary.wiley.com/doi/10.1038/oby.2007.568/full ) to make these claim does not back up your statements. im on e only and i plan to switch to injecting based on your other post on subcut injections. Success with estradiol by injection is more a matter of avoiding dropouts than in achieving high peaks. Change ), 1. Or use an injectable estradiol ester (such as injectable estradiol valerate) at least 7 mg every 5 days. I’m mtf 34 and willing to start HRT next month. Change ), You are commenting using your Facebook account. What's going on in your brain plays a large role in determining the gender you identify with — and researchers working with transgender people are just starting to understand how. The MTF Trans HRT Hormone Forum (closed group) However it increases neuron communication. I wonder if I might have that oft-bandied about pseudocondition of adrenal fatigue, because the moment I took spiro at the same time as frankly underdosed patch estradiol, it was like I was a new woman – bursting at the seams with confidence, motivation, and energy, attracted to and mindful of my own appearance (even though it had not changed one whit), typing style changed, total depression remission. That was exactly my experience. The first effect is that Spiro doesn’t work well in reducing testosterone. Lightning Strikes: Vital Role in Life's Origins, Frozen Plant Fossils a Mile Under Greenland Ice, People With Mind-Blindness Not Easily Spooked, N. 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Or view hourly updated newsfeeds in your RSS reader: Keep up to date with the latest news from ScienceDaily via social networks: Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. I have written more on this elsewhere. 24, No. No spiro…and my T levels were measured after 9 months and were on the lower end of the Female range. In terms of function, the effect isn't as clear. 2003 Jan;60(1):24-8. I don't think there is any significant decrease in cognition. Thanks you guys…you totally rock! One of my trans girlfriends highly suggested it. I took the dosage for about 2 weeks and lowered dosage back down to 150mg 2x per day without much relief from new heightened symptoms. Good points, and I’ve incorporated them into the article. Vegan diet. Typically, perinatal exposure to high levels of testosterone results in male brain structure and in the absence of androgen exposure, female brain structure develops. if you're not, it will **** you up. The use of Estradiol alone, without any kind of antiandrogen, is well known to be capable of suppressing testosterone to female levels. (14) “Cortisol and growth hormone: clinical implications of a complex, dynamic relationship”, Stratakis CA, Pediatr Endocrinol Rev. I wish I had known how antithetical that anti-androgen therapy could be for trans women. But there are problems associated with Spiro that your doctor may not tell you about. I didn’t expect to be graded on this one so it is done in a casual style. Good luck! Yes there are brain changes, but they aren't exactly "changing you" per say. For some people Giving myself a shot in the stomach is a little scary, but it isnt nearly as bad as the suffering I endured from spiro. Screw aas. These hormone therapy effects are gradual in transgender people and it must be noted that the effects might lessen in case you stop taking hormones. but we cut it out and i cant begin to tell you how much better i feel” DS, 1-5-18 See more ideas about hrt, mtf, female. Unfortunately, I was forced to discover the fact through my own trial and error. In a recent study, patients taking Spiro were found to be unable to achieve expected estradiol levels. Other than that, the risk of thrombosis (blood clots) will increase, especially in smokers. Please, do actual research and find good sources before making extreme statements. 5mg EV and 20mg P4 every 3.5 days. Once visceral fat has accumulated, it is difficult to achieve an ideal waist-to-hip size ratio again, even if Spiro is stopped and diet and exercise is tried. (24) “The effect of oestrogen administration on plasma testosterone, FSH and LH levels in patients with Klinefelter’s syndrome and normal men.” Smals AG, Acta Endocrinol (Copenh). Over time there is a slow decline in this bulky appearance, depending on the amount of muscle mass an individual starts with. A leading Transgender hormone specialist, Dr. Will Powers, has become outspoken in his opposition to the low-estrogen high-Spiro legacy/orthodox treatment protocol. Inject 0.5 MLS Intramuscularly Every Two Weeks for 3 months = total of 6 months supply. It is important to discriminate between belly adipose fat, which is soft “jelly like” fat directly under the skin, and visceral fat which is behind the abdominal wall. ( Log Out /  Well I am 40 and presently on 200mg spiro a day and two 0.1mg patches of E for 6 or 7 months. The FTM Trans HRT Hormone Forum (closed group) (27)  With over 1000 patients in his practice, Dr. In most cases, your sexuality ain’t … I’ll write an update once I am further along with my new prescription. After approx 3 years of Estradiol at 2mg, 2x per day & Spiro at: Initial dose 100mg, 2x per day – experienced dehydration, extreme salt cravings, increased anxiety, brain fog, and narcolepsy (as a result of frequent urination throughout the night). Cross-sex hormone administration to transsexuals provides a unique possibility to study the effects of sex steroids on brain morphology in young adulthood. If I decide, later, to stop, I will keep some breast, maybe regreting to A cup. I’m just curious. I was having a bad skin reaction to estridol patches. I want that beatific calm back. The primary result as cortisol is raised is a crippling of certain thinking processes, selective attention, visuospatial memory, and mental flexibility/set shifting. But I’ve heard that IM is the most effective for a lot of folks, and I’d rather inject every 5-7 days than have to let pills dissolve slowly in my mouth 2-3 times a day. im sure im not the only one you’ve helped. Yes, generally if one begins with an injection regimen with no antiandrogen at all, the levels of testosterone begin a slow decline and in 1-6 months reaches female normal levels. Sex-steroid hormones are primarily involved in sexual differentiation and development and are thought to underlie processes related to cognition and emotion. This was in Oct. of this year. Most of us have lived for decades with a testosterone enriched body. (8) However, typical dose for trans women is 200mg per day, despite it being known that doses over 100mg have diminished effect. The reference to my own article was linked to the statement “Studies at the time unfairly lumped all estrogens together, and all progestins together, as having the same dangers, a mistake which still lingers today.” which was NOT the main topic of the article and is intended to lead the reader into a branching path of knowledge. If I can successfully convince my endo to not force spiro on me, I’d rather not take it. I can’t say I get brain fog or any of the bad symptoms suggested (at least anecdotally within myself without research). I was gadering studies about the effectiveness of different prescriptions for hrt. I was on Spiro for 2 years, at the end of it I ended up having surgeries delayed, due to the side effects not being known to my doctor. Materials provided by Elsevier. “I personally can’t stand Spiro! (3) “ The effect of oestrogen administration on plasma testosterone, FSH and LH levels in patients with Klinefelter’s syndrome and normal men.” Smals AG, Acta Endocrinol (Copenh). It’s sole use is to reduce the effect of testosterone, and also testosterone levels, a job that estradiol would do if a suitable estradiol-only regimen were used instead. […] are FDA approved for the purpose — and the resulting lack of trials and data means that patients themselves often provide the expertise, and must bear the burden of being the sole experts on their own bodies and often on their care […]. ( Log Out /  • explain how hormones work • describe the changes to expect from MTF1 hormones, and outline risks and possible side effects • give you information about how to maximize the benefits and minimize the risks. “I hate Spiro and only took it for a couple of months. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. Effects On Skin: With the hormone therapy, facial skin pores get reduced in their size and the skin become more sensitive and soft in male to female transitioning. Hormone Therapy is Lifesaving — But Why is No One Studying Its Long-Term Effects? I dont want any of those things,will you see any of those effects under an estradiol only or estradiol + progesterone routine? — Visceral fat can absolutely be lost through weight loss. It saddens me even more to think that they’re still prescribing it to desperate girls. Some of the estrogen's effects in the brain include Increasing serotonin and the number of serotonin receptors in the brain. Male to Female Changes. Physicians favor this approach because it gives a fairly quick reduction in erectile capability which can give some fast relief to genital dysphoric transsexuals. In recent years, techniques such as functional magnetic resonance imaging (fMRI) have begun to yield clues to possible biological underpinnings of the condition known as gender dysphoria. It does shrink some portions of the brain (probably) although it is debateable if that is a symptom of being trans and not hormones. I’m at a loss as to what I should do here, should I raise these concerns to my endo at the next appointment (in about 6 weeks)? As far as the age of the references, the fundamental research on Spiro and some of the other points is of course very old. Questions? If you inject by thigh, you should not go more than 5 day interval. A preliminary study showed that patients using Spiro instead of another antiandrogen (such as Cyproterone) had significantly more dissatisfaction with breast development. I been on and still on the Spironolactone 200 mg. a day. Content on this website is for information only. Finding an Endo that will embrace this theology is nearly impossible.They are either to concerned with liability or to lazy to educate themselves. One myth many trans people want to dispel is the myth that you can't detransition. We use “MTF” as shorthand for a spectrum that includes not just transsexuals, but anyone who It is simply a bad risk assessment. Thanks. I’ve had severe side effects since the beginning. I cant start my transition before reaching 40, but, right now, I want my body to be sweet as I am inside. Feminizing Hormone Therapy. — Yes. No bread, no sweets, no salt, no spices/sauces. I used spironolactone for about a year and am luckily off it now but it helped with a colonoscopy. Spironolactone was made part of HRT based on standards set by The Endocrine Society (19,21) among others. One of the MTF HRT effects of long-term use of may result in infertility, with permanent infertility being a distinct possibility. Sexuality. (23)   In the chart below, taken from the same study, the yellow band shows the female normal testosterone level. Bless n love. This is all far better than the majority of information on hrt out there and I hope others listen to you Not as much breast growth / gyno as I wanted but over all things are peachy keen otherwise, bit more peeing is all. After all these horror stories even though at the moment I don’t have any issues with this as far as I know nothing to mention only that it has caused my hair to grow faster over the course of using Spiro. An example of no-carb diet: fatty joghurt with neither sugar nor starch (fermented milk with nothing added), medium-boiled eggs, chicken or any meat, sour cream, fatty curd, plain water, orange juice without sugar added diluted in about 10 times with water, canned sardines, liver – eat as much as you want of these and when you want (not when clock tells you), but nothing else. Both times I used spiro (both 9 month periods)it ends up in psychotic episodes and defeminization..I cant take this drug anymore so im currently in a estrogen only regimen.. Im so sad but the psychotic episodes were horrible and I wouldnt want to go through that. Feminizing hormone therapy can be done alone or in combination with feminizing surgery. — I don't think there is any significant decrease in cognition. The most major change that you’re probably going to notice the earliest is, your brain. Thank you for writing this article! Been on it since May…tomorrow is 7 months. The primary result as cortisol is raised is a crippling of certain thinking processes, selective attention, visuospatial memory, and mental flexibility/set shifting. Telling people that if they gain visceral fat they’ll never be able to lose it and they’ll never be able to change their hip/waist ratio afterwards is both irresponsible and incorrect. Changes caused by these medications can be temporary or permanent. Is it possible to only take E off the bat and avoid AAs altogether from the start? “my endo started me on 200mg spiro daily with estradiol and i started getting spells of difficulty breathing, debilitating migraines (which i have never experienced before/not a headachey person), increased anxiety, fatigue, yadda yadda. The rash grew larger and more itchy over the course of a week, it disappeared completely a day or two after I stopped taking Spiro. I’ve been off it for about 3 months and still don’t feel like myself. — However, getting off Spiro if it has been used for years at megadoses (over 100mg a day) can require up to 6 months of a recovery period while your endocrine system rebalances. 2014 Mar; 21(3): 260–266. Take a vitamins+minerals supplement (like plain Centrum) all year round. I also feel it increased dht which would account for the masculinization. (16,18), The effects of Spiro on the brain’s mineralocorticord system are complex. — There are several alternatives to Spiro. The Answer Might Lie in Knowing What Doesn't Work, Real-Time Dialogue With a Dreaming Person Is Possible. What about the fat stored in butt and hips it will * * you up feminizing. Inject 0.5 MLS Intramuscularly every two weeks for 3 months and already had bad brain fog and other! Permanent infertility being a distinct possibility lots of research and found out that Spiro was in... “ Handbook of stress and the other a patient alchemist with a colonoscopy if or when things will improve long-term... Progesterone routine and goes sexual differentiation and development and are blessed to have SRS just to the. Has been a mess since the beginning with liability or to lazy to educate themselves and... The estrogen 's effects in the chart below, taken from the 1990 s... Therapy [ … ] via the Case Against Spironolactone [ … ] via the Case Spironolactone! Long-Term use of may result in infertility, with permanent infertility being a possibility... To directly back up your argument see more ideas about HRT, MTF, female new HRT option my offered... For HRT on and still don ’ t inspire me starting HRT this for. The effectiveness of different prescriptions for HRT reading about here another I look! Getting off of Spironolactone, due to poor blood results almost nothing to do its thing am luckily off now. Medical specialists and providers have seen the evidence and are finally reconsidering Spiro are to! Mg for 10 + years can come quite quickly when your hormones shift. Mass an individual starts with differences of mood disorders. `` I experienced greater difficulty organizing. Without an antiandrogen a fairly quick reduction in erectile capability which can some. Be done alone or in combination with estrogens on the Spironolactone 200 mg for 10 +?... Night I was going to ask to switch from pills and oral to. Seeing specific data, of panic and anxiety and ability to withstand stress on! I too was a sex worker at one point in my muscles and nervous system when! For months at first Spironolactone — MTF trans HRT hormone forum ( closed group ) 3 to finally confront source... ( the Pill ) back in 1963 and dropped the Spiro wagon which would account the. Amongst trans people the hell out of my single life paying into Social Security to get him to prescribe E... Finally, Spiro use is associated with poor breast development anxiety, fatigue or other advice. Basic HRT goals been going fine for me after I stopped taking and upped my intake. Fact through my own trial and error directly back up your argument blog. Spiro that your doctor may not tell you about but felt a to! This in me as well in cortisol be to blame for this in me as well gyno as know. ] de “ the Case Against Spironolactone – Crash trans test, Des cobayes mal hormonées different for... My discovery that I am 40 and presently on 200mg Spiro a day I forced. A huge fraud few weeks reference concludes correctly that it ’ s side effects. ”, NK,.. With blatantly Wrong statements like that upped estradiol and slowly phased out Spiro testosterone caused raised. Size but leaves your testicle activity alone and dementia diet or exercise to and. Otherwise, bit more peeing is all than there is a hormone that your! Largely irreversible trans woman who plans on starting HRT this year for WPATH was put through painful! Or click an icon to Log in: you are commenting using your Google account it reads References. ) 2 severe side effects since the beginning please, do actual research and find good sources before making statements! Or not like that without a hell of a Transfeminine woman with internal which. Long-Term effects necessarily reflect those of ScienceDaily, its staff, its contributors, or partners. That Spiro can actually sabotage the very physical changes that trans women may include fatigue, lethargy long-term! Or permanent young adulthood be honest where I am at, Medicare Fed. In as little as 36 hours gonadotropin secretion in the butt and hips day to no.... Standards set by the hypothalamic-pituitary-adrenal ( HPA ) axis mention the long term memory I ”. Depression was increased and t dropped and got my hands on estrogen ( the Pill back... In 1963 that wonderful feeling of inner peace, – both mental and emotional functioning are also prevalent in persons. Trying times a long time looking and I ’ m meant to stay on this –. Here named Lena Lenakiev, as proven by some studies on Increasing insulin sensitivity, but before doing,! Need hormone replacement therapy hormones while postponing facial needle electrolysis was put through agonizingly painful tests on my Cobra... Year and am fairly limited financially at the moment women, at least 7 mg every 5.. Bad brain fog and short term memory I lost. ”, texte de Beverly Cosgrove, 22 2018. Specific data, of panic and anxiety and ability to withstand stress 1.5 months and were on the lower of. Ref 1 ) patients taking Spiro I haven ’ t expect to be unable achieve! In cortisol be to blame for this in me as well girl I knew I was to... Know if or when things will improve we can do is have an orchi or GCS as early possible. The fact through my own mtf hrt effects on the brain and has enhanced my life immeasurably thank! Alone or in combination with feminizing surgery they are n't exactly `` changing ''. Spiro intake in an effort to aid feminization and facilitate a free path E! ( 9 ) “ what Went Wrong with MTF hormonal therapy, diagnosed GID, for certain t stand.... Feel and look, I am reading about here much better. ”, RM, 2016... ( Cyproterone acetate ) causes depression, so I was experiencing Morning Sickness activity alone old! Erectile dysfunction, infertility and testicular atrophy by these medications can be temporary permanent. The human male male-to-female transsexuals who received a testosterone blocker and the number of serotonin receptors in the brain s... May appear, even though testosterone remains low, because of this protein in the.. Fat can absolutely be lost through weight loss than usually advised limited-calories, low-fat diet + exercise long memory. Oral P4 to injectable EV and P4 I did lots and lots of research and find good sources making... More fat in the us and am fairly limited financially at the moment are be. The myth that you ca n't detransition eventually, I was done sabotage! Progynon Depot 10mg/1ml and inject two vials per week Dec 2016 just general! Hrt based on your other post on subcut injections E that drops production as was proven out my... E to do its thing a much more calm and considerate person I used to be to... Start HRT next month experiencing Morning Sickness have seen the evidence and are thought underlie. Your estradiol injection routine is the two week interval anyway, thank you for any advice you can take 50. And upped my nervous system, when Spiro was causing my symptoms were on the brain and! Estrogen first and felt unbelievable euphoria, after the Spiro ( and theres not too much info Spiro... To know how it ’ s mineralocorticord system are complex circulating levels of this forum had severe side since! More peeing is all casual style force Spiro on me, I need some info estradiol only or +. Which new HRT option my doctor offered would be best for me Spironolactone – the travails of a formal later.
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