This is an old Reddit comment I wrote from elsewhere in response to a person asking about the recommended dosages for estradiol valerate and estradiol cypionate I chose for my introduction to hormone therapy for transfeminine … 24 years old, 14 months into estrogen monotherapy (plus a very brief stint with progesterone), and I officially have C-cups. estradiol cypionate injection (every one to two weeks) Endocrine Society guidelines specifically suggest that oral ethinyl estradiol should not be used in transfeminine people. Testosterone Enanthate or Cypionate IM or SC q 1 or 2 weeks, standard dose is 50 – 100 mg weekly Testosterone undeconoate (Aveed) 750 mg initial, 4 weeks, then q10 weeks. A low dose would be injecting less than 2mg every two weeks. The most common estrogens used in transgender women include estradiol (the predominant natural estrogen in women) and estradiol esters such as estradiol valerate and estradiol cypionate. Transdermal Testosterone Androderm ( 2 and 4 mg patches) 2-8mg daily Topical testosterone gels in packets and pumps, 50 –100 mg daily, Androgelpump Estradiol Cypionate: Also injected intramuscularly, a “typical” dose of estradiol cypionate is between 2 and 5mg every two weeks. Pills are convenient, cheap and effective, but are less safe if you smoke or are older than 35. Erin discusses the prescribing guidelines for, and the expected effects of, feminizing hormones 17 beta-Estradiol, Estradiol Valerate, and Estradiol Cypionate. You know, I often get dysphoric and think - among other things - that my breasts are small, but taking objective measurements like this really helps. Estrogen may be given as a pill, by injection, or by a number of skin preparations such as a gel, spray or a patch. 33" around the band and 36" around the girls. For women with hypogonadism, estrogen treatment continues for reproductive life up until natural menopausal age to maintain feminization and prevent bone loss, but choices of treatment often change from IM depot dosing to other dosage forms. (17- β estradiol) Valerate or cypionate Usual injectable (valerate) 5-20 mg IM q2 wks; up to 40 mg noted Usual injectable (cypionate): 2-10 mg IM qwk *Drug is on VA National Formulary; †Note: MtF estrogen doses are often higher than usual doses for hypogonadal conditions in biologic females. By Aly W. | First published December 21, 2018 | Last modified October 5, 2020. Estradiol Valerate versus Estradiol Cypionate: Dosage and Potency. Similarly to estradiol valerate, doses can be divided in half for weekly … It is involved in many of the physical and emotional changes seen in transition. Depo-Estradiol, a source of estradiol cypionate, is 5mg/mL, so the dose is probably around 5 mg every three weeks, less than half the recommended dose. In Episode 9, Erin Everett, NP-C, gives an overview of Feminizing Hormone Therapy medications for a Male to Female MtF Transition. Estrogen is the primary “female” hormone. These preparations may be administered orally, sublingually, topically (via patch or gel) , by intramuscular or subcutaneous injection, or by an implant. Just wow. The regimen also includes a normal dose of a recommended anti-androgen and a hormone-blocker used to prevent hair loss. For female hypogonadism, the usual dose is estradiol cypionate 1.5 to 2 mg IM every 4 weeks. Estrogen. Depo-Estradiol (Estradiol Cypionate Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Preface. The starting dose of estrogen can be maintained for 1-2 months, after which a dose increase can be considered barring any concerning effects. 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