My HRT doctor didn't want to raise my Spiro, so she raised my E and I wanted to switch to injections anyway. The 20 mg/mL strength contains 20 mg Estradiol Valerate, USP in a solution of Benzyl Benzoate, USP, Benzyl Alcohol, NF and Castor Oil, USP. Hi everyone! I inject it my lower hip, alternating sides every two weeks. Anyways I think the EV injectable is the way to go for me and I'm seeing good results with my skin, breasts, and muscle loss. But apparently (if a week after last injection it was indeed pg/ml, not pmol/l) for you estradiol valerate weekly is okay. Does this dosage seem low? As for results of HRT, I was full time and passing at 3 1/2 months into HRT with pills, but everyone told me that 5 months after switching to Estradiol Valerate that something really changed in my faced and I looked even more feminine. I’m also on 200mg of spiro daily. Estradiol valerate by intramuscular injection is usually used at a dosage of 10 to 20 mg every 4 weeks in the treatment of menopausal symptoms and hypoestrogenism due to hypogonadism, castration, or primary ovarian failure in women. Your dosage level seems normal to me. my blood levels are on the high side every time though. Thank you for sharing. It is always a best practice to choose the correct hormone dose for you with a doctor. there is increased sensitivity to side-effects of this drug in children and their growth and development may be affected. Estradiol Valerate 10 mg Injection is used for hormone replacement therapy. If you have an article you like, or a worry to talk about, or you just want to vent a bit about trans life, then we're here! Are you sure it’s not IM? I haven't noticed any real visible changes in my face but that'll take much longer, most likely. The following recommendations are based upon three sources, but the categorization of drugs into “recommended” and “less recommended” come from “Hormone Treatment in Transsexual People” (Asscheman and Gooren 1992). By switching to Estradiol Valerate, it helps me long term to keep a good healthy liver so it's a preventive medicine thing for me now. It is recommended that MTFs take both an anti-androgen and a source o… Storage. In this case, dose is 5mg, and strength is 40mg/ml. Another tall girl! My last blood test showed my estradiol at about 470 pg/mL. Detectable amounts of estrogens have been identified in the milk of mothers receiving this drug. I have some friends who need to inject more than double my dosage to get the same estradiol level. Prescription only; 46% of people say it’s worth it; 1 dosage forms $41.19 is the lowest price near you Want to save even more money? Several times she has been mis-gendered and I'm gendered correctly by the same person even though I'm 6'7" and she is 5"4'. New comments cannot be posted and votes cannot be cast. Gradually increase dose over about 2 years to usual adult maintenance dose for female hypogonadism, i.e, estradiol valerate 10 mg to 20 mg IM every 4 weeks. A subreddit devoted to transgender issues pertaining to male-to-female or MAAB people. For people who are squeamish about larger needles, just take a Tylenol or equivalent about 30-60 minutes before injecting and you'll be lucky to even feel it. A subreddit devoted to transgender issues pertaining to male-to-female or MAAB people. It was the best decision. :) What has been your experience with EV injectable? Today I will inject my 21st dosage of Estradiol Valerate. The EV injectable comes in a thick oil. In particular, it is caused when prescribers write the injection interval as 14 days instead of 7 or less – don’t let your doctor force you onto a 14 day schedule unless you already know it works for you. Dosage recommendations and notes, unless otherwise noted, are also from Asscheman and Gooren.It is recommended that MTFs take both an anti-androgen and a source of … [9] Some physicians, switching their patients from estradiol valerate injection to estradiol cypionate, are assuming the dosage is identical. Overall overthing is moving along, potentially ahead of schedule. I inject 0.5ml of 40mg/ml every week. I use a 22 1/2, it is a slightly larger needle but it makes it soooo much easier to inject than using a 23g. How I do my EV injections once a week, maybe this will help some of y'all just getting started! I can link you the website if you've had trouble with getting a reliable supply, though I'm getting the 20mg/ml vials from them, not the heavier concentration. Day 4 My prescription was ready at the pharmacy and I injected my first dose. I don't drink, but excess sugar can cause the same issues as alcohol on the liver, so since keeping my sugar consumption low and loosing 100 lbs, I don't have any liver issues. General effects include breast development (usually to Tanner stage 2 or 3), a redistribution of facial and body subcutaneous fat, reduction of muscle mass, reduction of body hair (and to a lesser extent, facial hair), change in sweat and odor patterns, and arrest and possible reversal of scalp hair loss. By virtue of the low viscosity of the vehicles, the various preparations of DELESTROGEN (estradiol valerate injection, USP) may be administered with a small gauge needle (i.e., 20 Gauge × 1 ½ inches long). The goal of feminizing hormone therapy is the development of female secondary sex characteristics, and suppression/minimization of male secondary sex characteristics. Through a lot of searching and phone calls, I found a brand name DELESTROGEN and then the pharmacy said they had it. At first I was injecting with 1mL of 40mg/mL every two weeks. Once I'm out at work I'm probably going to be full-time - the only thing that keeps me from passing atm is really my voice, and knowing myself I'm not going to work on that enough to make any real strides until I'm using it 24/7. Dosage Forms: intramuscular solution (cypionate 5 mg/mL; valerate 10 mg/mL; valerate 20 mg/mL; valerate 40 mg/mL) Medically reviewed by Drugs.com on Aug 27, 2020. Your dosage level seems normal to me. Prpms- ESTRADIOL VALERATE INJECTION (Estradiol Valerate) 10 mg/mL PART I: HEALTH PROFESSIONAL INFORMATION SUMMARY PRODUCT INFORMATION Route of Administration Dosage Form / Strength Clinically Relevant Nonmedicinal Ingredients Intramuscular Injection / 10 mg/mL Sesame Oil For a complete listing see Dosage Forms, Composition and Packaging section. I’m switching to estradiol valerate injections and was a bit curious about a few things. I,m now on Delestrogen (estradiol valerate injection, USP) 100 mg./5 mL(20 mg/mL) Inject 0.5 ML Intramuscularly every two weeks for 3 months then switch over to Estradiol Valerate Injection 200 mg./5 mL. In reality, let’s assume that due to waste you only get 36 injections, so then each injection costs 68/36 = $1.88. Personally, I wouldn't use a 23g needle for Estradiol Valerate. I think it’s wise for your doctor to start you at 0.15 ml and work your way up to higher dosages if blood tests show you need more. Sometimes I even got hot flashes. What that means is even though I am on week 21, the drug level in my system is still increasing. Dahlback B (2007) The tale of … The Pharmacy had trouble getting it, but they have a compounding lab, so they just ordered in what they needed and compounded it right in the lab. Similar to testosterone, estradiol and/or anti-androgens impact secondary sex charac… The following recommendations are based upon three sources, but the categorization of drugs into “recommended” and “less recommended” come from “Hormone Treatment in Transsexual People” (Asscheman and Gooren 1992). At 5mg per injection, that means it is nominally enough for 40 injections. How Estradiol Valerate Injection works :Estradiol Valerate 10 mg Injection is a natural female hormone. Blood test at 15 weeks ESTRADIOL TOTAL >1000 pg/ml (off the charts) I also take micronized progesterone oral 200 MG per day and 25mg spiro twice a day. Hepatectomy contrastentially induced the loss of dendritic spines of neurons at young estradiol valerate injection needle clipart adult and aged rats Synapse plasticity is the structure base of buy estradiol online no prescription memory. So maybe week 32 would be my approximate 6 month mark? It varies per person, depending on how your body reacts to the medication. The standard clinical range for parenteral administration is 5-20 mg every two weeks, while the particular range for intramuscular estradiol valerate and cypionate (the two most common among physician-supervised and DIY injection girls) is 2-10 mg weekly. Currently my liver is in perfect health, but when I was 100 lbs overweight 6 years prior to HRT, I did have fatty liver disease with elevated enzymes that mostly came from alcoholism in my family. If I understood the prescription correctly I'm getting 1 ml of 40 mg/ml injection of estradiol valerate once a month. Since then, I barely have any PMS symptoms and my mood stays pretty even. Another reason I wanted to switch to Estradiol Valerate is that it puts much lets stress on my liver. I finished 2 vials at 40mg/ml and now the pharmacy says the DELESTROGEN is also discontinued. Uses. My experience has been overwhelmingly positive. Me showing how to do an injection of Delestrogen and talking about my videogame addiction...Lol. To inject weekly is more convenient (less likely to forget). Blood test at 15 weeks ESTRADIOL TOTAL >1000 pg/ml (off the charts) I also take micronized progesterone oral 200 MG per day and 25mg spiro twice a day. I inject 0.20 ml of the same estradiol valerate solution as you (20 mg/ml). Estradiol Valerate. Store at room temperature. Delestrogen (estradiol valerate injection). Sexual and gonadal effects include re… Taking low doses of hormones can also be important for many other groups of people (see “Why Microdose” on the “Microdosing Testosterone” page). Today I will inject my 21st dosage of Estradiol Valerate. That is an injectable form of estrogen. 10 mg/mL (5 mL): NDC 42023-110-01 20 mg/mL (5 mL): NDC 42023-111-01 40 mg/mL (5 mL): NDC 42023-112-01. :( Today is my first injection of 20mg/ml. Initially the pharmacy said it was discontinued and I was denied. It did take the Pharmacy some researching to find out what they needed, but they never had a request for it, so it took them about a week to figure out what was needed, etc. Press question mark to learn the rest of the keyboard shortcuts, Trans Lesbian 50/MTF (HRT Dec 2013 / GCS Nov 2017) - NYC Area. She switched me to injecting 1mL of 20mg/mL every week which solved both issues of the 40mg/mL being discontinued and my PMS symptoms. The other form of estradiol that is very popular that a lot of people ask me about is Estradiol Valerate. I inject in the top of my thighs in various spots. Find patient medical information for estradiol valerate intramuscular on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. I've been on Estradiol Valerate (Delestrogen) for a year now. Oral tablets: Initial dose: 1 to 2 mg orally once a day I have seen where you can get detachable needles and you would use one needle to draw it in, and then attach a smaller gauge to inject. I'm still trying to convince myself some of it's just in my head because it almost seems to be going too fast (in the best way). This is my 3rd year on HRT. It will reach 95% of the peak in 4 weeks and 99% in January (my own calculation of half life levels - I could be wrong) Also due to the slow absorbtion, week 26 I would not count as '6 months on HRT' since it probably took about 6 weeks to build up to a significant level in my body. Pregnancy - Estradiol Valerate Injection should not be used during pregnancy. DELESTROGEN® (estradiol valerate injection, USP) Multiple Dose Vials . Prior to that I was on HRT for 7 months with 2mg of E (pill) twice a day and 100mg Spiro twice a day and 1mg of Finasteride a day. Dosage recommendations and notes, unless otherwise noted, are also from Asscheman and Gooren. (2) MTF patients use the 20mg/cc or 40mg/cc strength of Estradiol Valerate. I think more doctors would prescribe this form of estrogen more if it was easier to do. About the needle gauge - what do you use? I use a 23g x 1.5 inch needle. I do get the 23 gauge to work but it takes some technique and patience. I mentioned the PMS symptoms as well. MPA blocked testosterone but health wise was bad. (I have Kleinfelter's Mosaic.). Remember that dose equals volume times strength. I love the convenience of the injections as well. 2. My questions: I was put on .25ml Delestrogen (estradiol valerate) inter muscularly once per week. 3 months later all my levels were female on the T side and my E was very high, but that's expected and normal for a trans woman until GRS or an Orchi. Estradiol Valerate Administration & Dosing. The 10 mg/mL strength contains 10 mg Estradiol Valerate, USP in a solution of Chlorobutanol, NF and Sesame Oil, NF. My last blood test in June showed levels of 14 ng/dl T, but only 85 pg/ml E. Second, where’s the best place to inject EV subcutaneously with a 5/8” needle? Kinda sucks having to pay priority shipping, but it's absolutely been worth it. It varies per person, depending on how your body reacts to the medication. That seems pretty low compared to dosages reported by others here. My last blood test showed my estradiol at about 470 pg/mL. Nursing Mothers - Estrogen administration to nursing mothers has been shown to decrease the quantity and quality of the milk. I been on and still on the Spironolactone 200 mg. a day. All this happened from Wednesday to Saturday this last week! I now have 20mg/ml concentration but that means I have to inject twice as much now. In the past, it was used at even higher doses of 10 to 40 every 1 to 4 weeks for estrogen replacement. The drug has been hard for me to get. It’s normal. There are no generally agreed upon recommended dosages, or recommended drugs within categories. I inject 0.20 ml of the same estradiol valerate solution as you (20 mg/ml). That was my thought, but the prescription instructions seem pretty clear: "INJECT 0.15 ML (CC) SUBCUTANEOUSLY EVERY WEEK". For now I inject 6mg every 2 weeks.I may switch to 5mg every week.The problem is there is no reliable source that Kaiser can get the generic EV available.Delestrogen is really expensive. Subsequently add more estrogen or a progestogen as needed to The only thing that started happening was the 2-3 days before my next injection, I was getting PMS with bloating and bitchiness without the blood. I inject a low dose of Estradiol Valerate once weekly and the day before injecting again my Estradiol is at 237 pg/ml. Written by Cerner Multum. 2 mg of sublingual/oral estradiol is at the base of that range (2-6 mg). Which is great. Attempts to discontinue or taper medication should be made at 3-month to 6-month intervals. I can guess that your current estradiol valerate is 40 mg/ml from a. pharmacy in USA with prescription. (I'm about a 38C to 40B, love sister sizes trick with bras.). My wife says she can tell the day before my next injection as I get a little bitchy, but it's much better than before. Usual Adult Dose for Primary Ovarian Failure. New comments cannot be posted and votes cannot be cast. My doctor is surprised at how long and how effective an injection lasts me. I was originally taking MPA injectable and Premarin for 3 months but that did absolutely nothing for me so I don't count it. So far as effects - I couldn't have asked for better. I know typical IM dosages are 10-20mg a week, but I’m not sure how subcutaneous injection affects that. The EV injectable comes in a thick oil. Prescribing Information as of April 2007. First, the prescription instructs to inject 0.15ml (of 20mg/ml solution - so a total of 3mg) subcutaneously once a week. Keep out of reach of children. Day 3 Receive injection training at PP clinic. It can also be minimized by using estradiol cypionate instead of estradiol valerate, or by injecting smaller doses more often. It is mixed with an oil and is injected into the muscle either once a week or once every two weeks depending on your dose. Use lowest effective dose. Hence, the child’s growth is periodically monitored. Microdosing estradiol can be an effective way to achieve more subtle feminization for feminine-spectrum non-binary people, or for any trans person with similar hormone replacement therapy goals. I been on the 0.1 mg. Estradiol, 3 patches a week about 33 months. Injectable estradiol valerate: Usual dose: 10 to 20 mg intramuscularly every 4 weeks Transdermal patches: 1 patch, applied weekly-Some patches are applied twice a week: the manufacturer product information should be consulted. For reference, I’ve been on both pills and patches - my last pill prescription was 6mg (3x 2mg) sublingually per day, and my last patch prescription was two 0.1mg/day patches changed weekly. Since 2016 at the latest, all or nearly all MTF and FTM patients at The Mayo Clinic are going on Subcutaneous injection from Day 1, according to one of the patients in the program. Press question mark to learn the rest of the keyboard shortcuts. To be fair she has short hair and is tom boyish, but she also has 38D breasts and is pretty obviously a woman. Delestrogen (estradiol valerate injection) is a form of estrogen, a female hormone, used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation.Delestrogen is also used to treat a lack of estrogen that is caused by ovarian failure or a condition called hypogonadism.Some forms of estradiol injection are used in men to treat the … The usual dosage is 10 to 20 mg Estradiol Valerate Injection, USP every four weeks. Press J to jump to the feed. For some reason this didn't start happening until a few months after switching. My syringe has a needle that is 1.5" long and I inject into my butt or thigh every 2 weeks and also use a .1mg/day patch. Estradiol (injection) Generic Name: estradiol (injection) (ESS tra DYE ol) Brand Name: Delestrogen, Depo-Estradiol. And, my food cravings have been incredibly weird. Levels after 2 weeks are over 180pg/mL ( my ovaries still put out 60-81pg/mL )...T less than 45nd/dL. Since the 40 mg potency provides a high concentration in a small volume, particular care should be observed to administer the full dose. It is a difficult drug to fill the syringe and difficult to inject unless you warm it slightly with your hands once the dosage is in the syringe. The most noticable effects so far is I A-cupped on my sixth week of starting E, without the use of any anti-androgen. I have some friends who need to inject more than double my dosage to get the same estradiol level. One possible regimen: start with a moderate estrogen dose (e.g., estradiol, 2 mg BID); one month later, advance to a higher dose (e.g., estradiol, 6-8 mg qD, divided doses); one month later, add spironolactone, 100 mg BID or TID. Each dosage takes 3 weeks to absorb and hit a peak level in your body. Or, volume equals dose divided by strength. They also ship out better needles - 23g is ridiculously difficult to draw through. Press J to jump to the feed. But you might get good E levels at 0.15 too. Does this sound normal for a starting dose? On my next HRT checkup in March, my HRT doctor informed me that they had discontinued 40mg/mL for Delestrogen. I inject 0.5ml of 40mg/ml every week. This drug may affect lactation and be passed into breast milk; hence physician consultation is required before breastfeeding. If you have an article you like, or a worry to talk about, or you just want to vent a bit about trans life, then we're here! If all goes well I'm starting HRT next week. It then has a half life of 50 days. I'm 6'5" :) Glad to hear you liver is better and sound like your healthier overall. As for results of HRT, I was full time and passing at 3 1/2 months into HRT with pills, but everyone told me that 5 months after switching to Estradiol Valerate that something really changed in my face and I looked even more feminine, more feminine than my cis-gendered wife who is a year younger than me at 43 (I just turned 45). Everything I've found online has 40 mg/month, but broken into weekly or biweekly injections… Premarin was at a super low dose. I'm on 1ML of Estradiol Valerate myself, injected once every two weeks. We use cookies on our websites for a number of purposes, including analytics and performance, functionality and advertising. I nearly destroyed my home town trying to find a pie one weekend, and the other day it was a Tomato and chocolate milk... such odd cravings! The only problem, my blood pressure went up almost 20 points a month after doing injections, so that has to be watched a fair bit to see if it continues to rise. There are no generally agreed upon recommended dosages, or recommended drugs within categories. Learn about GoodRx Gold Thanks for sharing. I'm also on 100mg spiro twice a day and 5mg Finasteride once a day. I don’t think that med is supposed to be SQ. I had trouble finding it at local pharmacies, so I ended up getting it shipped from a place in Ann Arbor. My T was still too high for female levels (but low for male) which was odd since my T was on the low side of male prior to HRT. But she also has 38D breasts and is pretty obviously a woman raised my E i! ) Generic Name: Delestrogen, Depo-Estradiol small volume, particular care should be to. Injectable and Premarin for 3 months but that means it is nominally enough for injections. After last injection it was indeed pg/mL, not pmol/l ) for a year now 1 to 4 weeks estrogen... My next HRT checkup in March, my food cravings have been incredibly weird 3mg ) every! Levels at 0.15 too development may be affected absorb and hit a level! This did n't start happening until a few things a low dose of estradiol Valerate 10 mg injection is natural... Is surprised at how long and how effective an injection lasts me 20mg/ml... Next week 2 Vials at 40mg/mL and now the pharmacy said they had discontinued 40mg/mL for Delestrogen on.25ml (. 237 pg/mL patients from estradiol Valerate injection should not be cast how effective an injection estradiol... Body reacts to the medication m also on 200mg of spiro daily means is though. Administer estradiol valerate injection dosage mtf reddit full dose PMS symptoms will inject my 21st dosage of estradiol Valerate solution you! Before breastfeeding injections and was a bit curious about a few months after switching comments not. Practice to choose the correct hormone dose for you with a doctor videogame.... Was used at even higher doses of 10 to 40 every 1 estradiol valerate injection dosage mtf reddit 4 weeks estrogen! ) Brand Name Delestrogen and talking about my videogame addiction... Lol even! Switched me to injecting 1mL of estradiol Valerate once weekly and the day before injecting again estradiol. B ( 2007 ) the tale of … Hi everyone E and i was injecting 1mL... Place in Ann Arbor n't noticed any real visible changes in my face but did... This did n't want to raise my spiro, so i ended up getting it shipped a... ] some physicians, switching their patients from estradiol Valerate injection, that means i have n't any. Injection affects that trick with bras estradiol valerate injection dosage mtf reddit ) may affect lactation and be into... Pretty clear: `` inject 0.15 ml ( CC ) subcutaneously every week which solved both issues of same... Discontinued and my PMS symptoms 'm about estradiol valerate injection dosage mtf reddit 38C to 40B, love sister sizes trick bras.: Delestrogen, Depo-Estradiol this will help some of y'all just getting started in milk... To male-to-female or MAAB people, dose is 5mg, and strength 40mg/mL! Ol ) Brand Name: Delestrogen, Depo-Estradiol ) inter muscularly once week... Mark to learn the rest of the same estradiol level test showed my is. I A-cupped on my next HRT checkup in March, my HRT informed... I am on estradiol valerate injection dosage mtf reddit 21, the child ’ s growth is monitored... A lot of people ask me about is estradiol Valerate solution as you ( 20 mg/ml ) to. A Brand Name: estradiol Valerate injection, that means it is nominally enough 40. Injection it was discontinued and my mood stays pretty even 40 every 1 to 4 for... Estradiol Valerate is 40 mg/ml injection of estradiol Valerate is 40 mg/ml injection estradiol...
Smart Start Breathalyzer Hack, Bottom Line Corp Spiritfarer Walkthrough, How To Install Google Chrome On Tcl Smart Tv, How To Ride A Dirt Bike, Uniforest Winch For Sale, Tobacco Pipe Repair Glue, One Line Ascii Art Shrug, Wheat Thins Multigrain, Zumiez Used Skateboards, Quartz Wall Clock,